Neurotoxicity and lethality of toxic extracts from atlantic coast shellfish
Identifieur interne : 004A53 ( Main/Exploration ); précédent : 004A52; suivant : 004A54Neurotoxicity and lethality of toxic extracts from atlantic coast shellfish
Auteurs : Ran Jan Bose [Canada] ; Gary B. Glavin [Canada] ; Carl Pinsky [Canada]Source :
- Progress in Neuropsychopharmacology & Biological Psychiatry [ 0278-5846 ] ; 1989.
Abstract
1. HCl-extract of poisonous shellfish was injected i.p. into Swiss-Webster mice.2. Behavioral effects (sluggishness, scratching, huddling, clonic convulsions, respiratory distress and mortality) were noted.3. Infant mice were more sensitive than were the adults to XTRT toxicity. Estimated LD50 values were; adult; 34.8 ml/kg i.p., infant: 9.6 ml/kg i.p.4. The mouse model of shellfish-toxicity offers the advantages of a degree of similarity with the human clinical situation and a rapid time course for screening antagonists against shellfish poisoning.
Url:
DOI: 10.1016/0278-5846(89)90146-2
Affiliations:
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Glavin</name></author><author><name sortKey="Pinsky, Carl" sort="Pinsky, Carl" uniqKey="Pinsky C" first="Carl" last="Pinsky">Carl Pinsky</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:FE3EFEDE9D409530824EA9262018497836CB268A</idno><date when="1989" year="1989">1989</date><idno type="doi">10.1016/0278-5846(89)90146-2</idno><idno type="url">https://api-v5.istex.fr/document/FE3EFEDE9D409530824EA9262018497836CB268A/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001358</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001358</idno><idno type="wicri:Area/Istex/Curation">001358</idno><idno type="wicri:Area/Istex/Checkpoint">002153</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002153</idno><idno type="wicri:doubleKey">0278-5846:1989:Bose R:neurotoxicity:and:lethality</idno><idno type="wicri:Area/Main/Merge">005404</idno><idno type="wicri:Area/Main/Curation">004A53</idno><idno type="wicri:Area/Main/Exploration">004A53</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Neurotoxicity and lethality of toxic extracts from atlantic coast shellfish</title><author><name sortKey="Bose, Ran Jan" sort="Bose, Ran Jan" uniqKey="Bose R" first="Ran Jan" last="Bose">Ran Jan Bose</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Pharmacology and Therapeutics, Winnipeg</wicri:regionArea><wicri:noRegion>Winnipeg</wicri:noRegion></affiliation><affiliation wicri:level="4"><country>Canada</country><wicri:regionArea>Inquires and reprint requests should be addressed to: Dr. Ranjan Bose, Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, 770 Bannatyne Avenue, Winnipeg, Manitoba</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Glavin, Gary B" sort="Glavin, Gary B" uniqKey="Glavin G" first="Gary B." last="Glavin">Gary B. Glavin</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Surgery, University of Manitoba, Winnipeg</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Pinsky, Carl" sort="Pinsky, Carl" uniqKey="Pinsky C" first="Carl" last="Pinsky">Carl Pinsky</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Pharmacology and Therapeutics, Winnipeg</wicri:regionArea><wicri:noRegion>Winnipeg</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Progress in Neuropsychopharmacology & Biological Psychiatry</title><title level="j" type="abbrev">PNP</title><idno type="ISSN">0278-5846</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1989">1989</date><biblScope unit="volume">13</biblScope><biblScope unit="issue">3–4</biblScope><biblScope unit="page" from="559">559</biblScope><biblScope unit="page" to="562">562</biblScope></imprint><idno type="ISSN">0278-5846</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0278-5846</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">1. HCl-extract of poisonous shellfish was injected i.p. into Swiss-Webster mice.2. Behavioral effects (sluggishness, scratching, huddling, clonic convulsions, respiratory distress and mortality) were noted.3. Infant mice were more sensitive than were the adults to XTRT toxicity. Estimated LD50 values were; adult; 34.8 ml/kg i.p., infant: 9.6 ml/kg i.p.4. The mouse model of shellfish-toxicity offers the advantages of a degree of similarity with the human clinical situation and a rapid time course for screening antagonists against shellfish poisoning.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Manitoba</li></region><settlement><li>Winnipeg</li></settlement><orgName><li>Université du Manitoba</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Bose, Ran Jan" sort="Bose, Ran Jan" uniqKey="Bose R" first="Ran Jan" last="Bose">Ran Jan Bose</name></noRegion><name sortKey="Bose, Ran Jan" sort="Bose, Ran Jan" uniqKey="Bose R" first="Ran Jan" last="Bose">Ran Jan Bose</name><name sortKey="Glavin, Gary B" sort="Glavin, Gary B" uniqKey="Glavin G" first="Gary B." last="Glavin">Gary B. Glavin</name><name sortKey="Pinsky, Carl" sort="Pinsky, Carl" uniqKey="Pinsky C" first="Carl" last="Pinsky">Carl Pinsky</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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